Non-selective beta blockers and mortality in decompensated Cirrhosis: Is Cirrhotic Cardiomyopathy the missing link?
نویسندگان
چکیده
منابع مشابه
Is the use of non-selective beta-blockers necessary in cirrhotic patients with small varices?
Non-selective β-blockers (NSBBs) could eff ectively prevent the development of fi rst variceal bleeding in cirrhotic patients with medium/large varices. However, as recently reviewed by Giannelli et al [1], the clinical benefi t of NSBBs remains controversial in cirrhotic patients with small varices. In line with their considerations, we would like to further comment on the controversy. A previ...
متن کاملBeta-blockers in liver cirrhosis
Since the original description of the effectiveness of β-blockers in lowering the portal pressure and therefore the risk of variceal bleeding, more than 500 articles in the English literature on the use of non selective β-blockers (NSBB) in cirrhosis have been published. The use of NSBB in pre-primary prophylaxis of variceal bleeding is currently not indicated. In primary prophylaxis, patients ...
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Cirrhotic cardiomyopathy is impaired contractile responsiveness to stress, diastolic dysfunction and electrophysiological abnormalities in the absence of known cardiac disease in cirrhotic patients. This Descriptive case series study was conducted in sree balaji medical college and hospitals. This study included 74 consecutive cases of cirrhosis of liver of either sex above 14 years of age. Fir...
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BACKGROUND/AIMS The blunted ventricular systolic and diastolic contractile responses to physical and pharmacological stress in cirrhosis are termed cirrhotic cardiomyopathy (CCM). CCM has been known to involve multiple defects in the β-adrenergic signaling pathway. The aim of this study was to determine whether cirrhotic patients have blunted cardiac responses to catecholamine stimulation throu...
متن کاملNonselective Beta-blockers in Patients with Cirrhosis: "the Therapeutic Window".
For over 30 years, nonselective beta-blockers (NSBB) have been successfully used for preventing variceal bleeding in patients with cirrhosis and portal hypertension. Nevertheless, recent studies suggest that NSBB may be effective only within a particular "therapeutic window" in patients with advanced liver disease. Outside of this window, in early stages of cirrhosis and in very advanced cirrho...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2021
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2021.04.025